Colchicine.

Colchicine is a highly poisonous water-soluble alkaloid found in plants of the genus Colchicum (autumn crocus, meadow saffron) with the chemical formula C22H25NO6. The chemical magnetise up or common name for colchicine is (S) N-(5,6,7,9-tetrahydro- 1,2,3, IO-tetramethoxy-9-oxobenzo [alpha] heptaien-7-yl) acetamide. The molecular angle of it is 399.2 grams. Colchicine has 4 isomers,each pair has either R or S configuration.(-)-(aS,7S)-Colchicine is the vivid isomer which can interconvert between aR and aS * C22H25NO6 * molecular weight is 399.4426 * melting point is 142 degrees Celsius * water solubility is little than 10/g mL at 21 degrees Celsius * picket yellow to greenish crystalline powder * photosenstive * slowly hyrdolyzes in acidic solution * First apply over 2000 eld ago * derived form preparations of Colchicum autumnale * First depict by Padanius Dioscordes (AD 54-68), a Greek surgeon, in De Materia Medica * currently produced locally by Sigma Uses: * Treatment of gout * Treatment of Familial Mediterranean pyrexia * minimally effective chemotherapy agent * research use as an antimitotic agent * new uses universe explored - chronic hepatitis B and cirrhosis of the liver - Sweets syndrome - pediatric pericarditis - constipation Symptoms: * Nausea * diarrhea * pancytopenia * alopecia * weakness * respiratory distress - potentially fatal Is shared out into 3 phases: * demonstrate I is the G.I.

Phase - occurs within hours of ingestion * stage II is the multi-phase stage - cardiovascular lack - respiratory insufficiency - metabolic effectuate - neuromuscular effects - hematologic effects * Stage III is the recovery phase: - occurs 7 to 10 days after ingestion - marked by alo! pecia - echo leukocytosis Mechanism of toxicity: * Metabolized in the liver - facilitated by cytochrome P450 - undergoes deacetylation and hydrolysis - born-again to oxydicolchicine Recirculated in Liver: * Significant follow absorbed in the digestive tract *... No real enthusiasm in this essay, it mearly stated things. If this was an AP essay for chemistry that would be fine. If you want to ride a full essay, order it on our website: OrderEssay.net

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